Scientists have been studying for the past decade the effect that the cannabinoid cannabidiol has on bone healing and development. It seems scientists can agree that CBD can accelerate the process of the body healing broken bones and making them stronger.
A study that was published in the February 2009 issue of International Immunopharmacology tested the effects of 5 milligrams of cannabidiol in a periodontitis experimental model in rats. After 30 days a morphometrical analysis of alveolar bone loss demonstrated that CBD treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor kB ligand RANKL/RANK. Gingival tissues also showed decreased neutrophil migration associated with lower interleukin and tumor necrosis factor-a production.
Another study conducted in 2009 and published online with PNAS showed endocannabinoids activate GTPyS binding via the GPR55 receptor. The study concluded that the cannabinoid receptors CB1 and CB2 affect bone metabolism. Stimulatory effects on osteoclast function were attenuated by CBD. GPR55 suppresses osteoclast formation but stimulates osteoclast formation. This report also states that CBD significantly reduced bone absorption in vivo.
The Journal of Bone and Mineral Research published a study showing that the cannabinoid cannabidiol (CBD) strengthens bones and accelerates the healing of fractures.
Scientists investigated the therapeutic effects of CBD on a sublesional bone loss in a rat model with spinal cord injury. It was shown that CBD enhanced bone volume, trabecular thickness, trabecular number, and reduced trabecular separation in proximal tibiae. It also increased ultimate compressive load, stiffness, and energy to max force of femoral diaphysis.
Studies conducted throughout the years show how useful cannabinoid therapy can be to help in bone fragment healing by increasing the volume and thickness of trabecular bone and the presence of unabsorbed cartilage. It has also been seen that CBD increases the strength of healed femurs, and may be of therapeutic value to spinal cord injuries as it lessens the loss of bone mineral that occurs in these injuries.
CBD was found to enhance fracture healing through the stimulation of Lysyl Hydroxylase, a prominent enzyme that is directly involved in bone healing and is present in all bone-building cells (known as osteoblasts). Through such stimulation, osteoblast cells were kickstarted in the healing process, enhancing the healing process and causing collagen cells to form stronger, healthier bones throughout the healing of the fracture.
In addition, researchers used 3D X-ray imaging techniques to measure the density of bone calluses following CBD administration. Bone callus density is very significant in bone healing, as it forms the “bridge” over the fracture, thus causing it to heal.
Skeletal regeneration and tissue repair are only the tip of the iceberg in the therapeutic benefits that CBD has to offer, and it is only with continued research that we may someday find ways to better treat even the most notorious problems in human health.